Design, Characterization and In-vitro Evaluation of Favipiravir Orodispersible Films

Introduction: Orodispersible films (ODF) is a thin strip that mostly transparent, biodegradable and it has hydrophilic polymers disintegrate dissolves immediately when getting in contact with saliva. Different disintegrants play crucial role film properties such as organoleptic properties, thickness, particular disintegration time of the film. The main reason for development oral their prominent increased patient compliance among pediatrics geriatrics by disintegrating faster, releasing drug rapidly, without need water, decreasing risk choking.
 Aim: To formulate orodispersible favipiravir to study effect different superdisintegrants on various properties.
 Methods: method used prepare solvent casting method. In this method, solution prepared using polymer, drug, superdisintegrants. This casted film-forming apparatus spreader an instrument obtain film.
 Results: weights ranging from 148mg 237mg based superdisintegrant concentration. pH didn’t vary significantly percent moisture absorption doesn’t have significant variation. However, texture varied smooth rough transparent translucent. Disintegration varying 28 42 seconds. optimum batch formulation gave 98% release.